Mechanistic Differences between Nucleic Acid Chaperone Activities of the Gag Proteins of Rous Sarcoma Virus and Human Immunodeficiency Virus Type 1 Are Attributed to the MA Domain

Host cell tRNAs are recruited for use as primers to initiate reverse transcription in retroviruses. Human immunodeficiency virus type 1 (HIV-1) uses tRNA(Lys3) as the replication primer, whereas Rous sarcoma virus (RSV) uses tRNA(Trp). The nucleic acid (NA) chaperone function of the nucleocapsid (NC...

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Autores principales: Rye-McCurdy, Tiffiny D., Nadaraia-Hoke, Shorena, Gudleski-O'Regan, Nicole, Flanagan, John M., Parent, Leslie J., Musier-Forsyth, Karin
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2014
Materias:
Genome Replication and Regulation of Viral Gene Expression
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4097784/
https://ncbi.nlm.nih.gov/pubmed/24789780
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00736-14
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