Promotion of a Subdominant CD8 T Cell Response during Murine Gammaherpesvirus 68 Infection in the Absence of CD4 T Cell Help

CD8 and CD4 T cells are each critically important for immune control of murine gammaherpesvirus 68 (γHV68) infection. In immunocompetent mice, acute γHV68 infection results in lifelong latency, but in the absence of CD4 T cell help, mice succumb to viral recrudescence and disease. However, the requi...

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Bibliographic Details
Main Authors: Freeman, Michael L., Roberts, Alan D., Burkum, Claire E., Woodland, David L., Blackman, Marcia A.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2014
Subjects:
Pathogenesis and Immunity
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4097778/
https://ncbi.nlm.nih.gov/pubmed/24789784
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00690-14
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