Response to BRAF inhibition in melanoma is enhanced when combined with immune checkpoint blockade

BRAF-targeted therapy results in objective responses in the majority of patients, however the responses are short-lived (~6 months). In contrast, treatment with immune checkpoint inhibitors results in a lower response rate, but the responses tend to be more durable. BRAF inhibition results in a more...

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Hlavní autoři: Cooper, Zachary A., Juneja, Vikram R., Sage, Peter T., Frederick, Dennie T., Piris, Adriano, Mitra, Devarati, Lo, Jennifer A., Hodi, F. Stephen, Freeman, Gordon J., Bosenberg, Marcus W., McMahon, Martin, Flaherty, Keith T., Fisher, David E., Sharpe, Arlene H., Wargo, Jennifer A.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2014
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4097121/
https://ncbi.nlm.nih.gov/pubmed/24903021
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2326-6066.CIR-13-0215
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