Apigenin induces DNA damage through the PKCδ-dependent activation of ATM and H2AX causing down-regulation of genes involved in cell cycle control and DNA repair

Apigenin, an abundant plant flavonoid, exhibits anti-proliferative and anti-carcinogenic activities through mechanisms yet not fully defined. In the present study, we show that the treatment of leukemia cells with apigenin resulted in the induction of DNA damage preceding the activation of the apopt...

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Bibliografiska uppgifter
Huvudupphovsmän: Arango, Daniel, Parihar, Arti, Villamena, Frederick A., Wang, Liwen, Freitas, Michael A., Grotewold, Erich, Doseff, Andrea I.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2012
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4097023/
https://ncbi.nlm.nih.gov/pubmed/22985621
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bcp.2012.09.005
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