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CD14 enhances cellular responses to endotoxin without imparting ligand-specific recognition.

Binding of the lipid A portion of bacterial lipopolysaccharide (LPS) to leukocyte CD14 activates phagocytes and initiates the septic shock syndrome. Two lipid A analogs, lipid IVA and Rhodobacter sphaeroides lipid A (RSLA), have been described as LPS-receptor antagonists when tested with human phago...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Delude, R L, Savedra, R, Zhao, H, Thieringer, R, Yamamoto, S, Fenton, M J, Golenbock, D T
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1995
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC40970/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7568119/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.92.20.9288
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