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ACUTE DYSKERIN DEPLETION TRIGGERS CELLULAR SENESCENCE AND RENDERS OSTEOSARCOMA CELLS RESISTANT TO GENOTOXIC STRESS-INDUCED APOPTOSIS

Dyskerin is a conserved, nucleolar RNA-binding protein implicated in an increasing array of fundamental cellular processes. Germline mutation in the dyskerin gene (DKC1) is the cause of X-linked dyskeratosis congenita. Conversely, wild-type dyskerin is overexpressed in sporadic cancers, and high-lev...

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Detalhes bibliográficos
Main Authors: Lin, Ping, Mobasher, Maral E., Alawi, Faizan
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4096983/
https://ncbi.nlm.nih.gov/pubmed/24690175
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2014.03.114
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