Discovery of Potent Anticancer Agent HJC0416, an Orally Bioavailable Small Molecule Inhibitor of Signal Transducer and Activator of Transcription 3 (STAT3)

In a continuing effort to develop orally bioavailable small-molecule STAT3 inhibitors as potential therapeutic agents for human cancer, a series of novel diversified analogues based on our identified lead compound HJC0149 (1) (5-chloro-N-(1,1-dioxo-1H-1λ(6)-benzo[b]thiophen-6-yl)-2-hydroxybenzamide,...

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Hlavní autoři: Chen, Haijun, Yang, Zhengduo, Ding, Chunyong, Xiong, Ailian, Wild, Christopher, Wang, Lili, Ye, Na, Cai, Guoshuai, Flores, Rudolfo M., Ding, Ye, Shen, Qiang, Zhou, Jia
Médium: Artigo
Jazyk:Inglês
Vydáno: 2014
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4096847/
https://ncbi.nlm.nih.gov/pubmed/24904966
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejmech.2014.05.049
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