Enhanced risk profiling of implanted defibrillator shocks with circulating SCN5A mRNA splicing variants: a pilot trial

OBJECTIVES: The aim of this study was to determine the association of SCN5A cardiac sodium (Na(+)) channel mRNA splice variants in white blood cells (WBCs) with risk of arrhythmias in heart failure (HF). BACKGROUND: HF is associated with upregulation of two cardiac SCN5A mRNA splice variants. that e...

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Autors principals: Gao, Ge, Brahmanandam, Vikram, Raicu, Mihai, Gu, Lianzhi, Zhou, Li, Kasturirangan, Srinivasan, Shah, Anish, Negi, Smita I., Wood, Melissa R., Desai, Ankit A., Tatooles, Antone, Schwartz, Alan, Dudley, Samuel C.
Format: Artigo
Idioma:Inglês
Publicat: 2014
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4096784/
https://ncbi.nlm.nih.gov/pubmed/24703920
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jacc.2014.02.588
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