Structural insights into the stabilization of MALAT1 noncoding RNA by a bipartite triple helix

Metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) is a highly-abundant nuclear long noncoding RNA that promotes malignancy. A 3′-stem-loop structure is predicted to confer stability by engaging a downstream A-rich tract in a triple helix, similar to the expression and nuclear retention...

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Hlavní autoři: Brown, Jessica A., Bulkley, David, Wang, Jimin, Valenstein, Max L., Yario, Therese A., Steitz, Thomas A., Steitz, Joan A.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2014
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4096706/
https://ncbi.nlm.nih.gov/pubmed/24952594
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.2844
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