Á lódáil...
Determinants of buildup of the toxic dopamine metabolite DOPAL in Parkinson’s disease
Intra-neuronal metabolism of dopamine (DA) begins with production of 3,4-dihydroxyphenylacetaldehyde (DOPAL), which is toxic. According to the ‘catecholaldehyde hypothesis,’ DOPAL destroys nigrostriatal DA terminals and contributes to the profound putamen DA deficiency that characterizes Parkinson’s...
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| Main Authors: | , , , , , , , , |
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| Formáid: | Artigo |
| Teanga: | Inglês |
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2013
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| Ábhair: | |
| Rochtain Ar Líne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4096629/ https://ncbi.nlm.nih.gov/pubmed/23786406 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jnc.12345 |
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