Determinants of buildup of the toxic dopamine metabolite DOPAL in Parkinson’s disease

Intra-neuronal metabolism of dopamine (DA) begins with production of 3,4-dihydroxyphenylacetaldehyde (DOPAL), which is toxic. According to the ‘catecholaldehyde hypothesis,’ DOPAL destroys nigrostriatal DA terminals and contributes to the profound putamen DA deficiency that characterizes Parkinson’s...

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Autori principali: Goldstein, David S., Sullivan, Patti, Holmes, Courtney, Miller, Gary W., Alter, Shawn, Strong, Randy, Mash, Deborah C., Kopin, Irwin J., Sharabi, Yehonatan
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2013
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4096629/
https://ncbi.nlm.nih.gov/pubmed/23786406
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jnc.12345
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