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Impaired lipoprotein receptor-mediated peripheral binding of plasma Aβ is an early biomarker for mild cognitive impairment preceding Alzheimer’s disease
Soluble circulating low density lipoprotein receptor-related protein-1 (sLRP) provides key plasma binding activity for Alzheimer’s disease (AD) amyloid β-peptide (Aβ). sLRP normally binds 70–90% of plasma Aβ preventing free Aβ access to the brain. In AD, Aβ binding to sLRP is compromised by increase...
Kaydedildi:
| Asıl Yazarlar: | , , , , , |
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| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
2011
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4096563/ https://ncbi.nlm.nih.gov/pubmed/21157031 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3233/JAD-2010-101248 |
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