Impaired lipoprotein receptor-mediated peripheral binding of plasma Aβ is an early biomarker for mild cognitive impairment preceding Alzheimer’s disease

Soluble circulating low density lipoprotein receptor-related protein-1 (sLRP) provides key plasma binding activity for Alzheimer’s disease (AD) amyloid β-peptide (Aβ). sLRP normally binds 70–90% of plasma Aβ preventing free Aβ access to the brain. In AD, Aβ binding to sLRP is compromised by increase...

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Hlavní autoři: Sagare, Abhay P., Deane, Rashid, Zetterberg, Henrik, Wallin, Anders, Blennow, Kaj, Zlokovic, Berislav V.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2011
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4096563/
https://ncbi.nlm.nih.gov/pubmed/21157031
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3233/JAD-2010-101248
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