GSK3β controls epithelial-mesenchymal transition and tumor metastasis by CHIP-mediated degradation of Slug

Glycogen synthase kinase 3 beta (GSK3β) is highly inactivated in epithelial cancers and is known to inhibit tumor migration and invasion. The zinc-finger-containing transcriptional repressor, Slug, represses E-cadherin transcription and enhances epithelial-mesenchymal transition (EMT). In this study...

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Autors principals: Kao, Shih-Han, Wang, Wen-Lung, Chen, Chi-Yuan, Chang, Yih-Leong, Wu, Yi-Ying, Wang, Yi-Ting, Wang, Shu-Ping, Nesvizhskii, Alexey I, Chen, Yu-Ju, Hong, Tse-Ming, Yang, Pan-Chyr
Format: Artigo
Idioma:Inglês
Publicat: 2013
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4096338/
https://ncbi.nlm.nih.gov/pubmed/23851495
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2013.279
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