Easily Accessible Polycyclic Amines that Inhibit the Wild-Type and Amantadine-Resistant Mutants of the M2 Channel of Influenza A Virus

[Image: see text] Amantadine inhibits the M2 proton channel of influenza A virus, yet most of the currently circulating strains of the virus carry mutations in the M2 protein that render the virus amantadine-resistant. While most of the research on novel amantadine analogues has revolved around the...

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Main Authors: Rey-Carrizo, Matias, Barniol-Xicota, Marta, Ma, Chunlong, Frigolé-Vivas, Marta, Torres, Eva, Naesens, Lieve, Llabrés, Salomé, Juárez-Jiménez, Jordi, Luque, Francisco J., DeGrado, William F., Lamb, Robert A., Pinto, Lawrence H., Vázquez, Santiago
Formato: Artigo
Idioma:Inglês
Publicado: American Chemical Society 2014
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4096222/
https://ncbi.nlm.nih.gov/pubmed/24941437
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm5005804
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