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Exploring the Requirements for the Hydrophobic Scaffold and Polar Amine in Inhibitors of M2 from Influenza A Virus

[Image: see text] Inhibitors targeting the influenza A virus M2 (A/M2) proton channel have lost their effectiveness due to widespread resistance. As a first step in the development of new inhibitors that address this problem, we have screened several focused collections of small molecules using two-...

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Detalhes bibliográficos
Main Authors: Wang, Jun, Ma, Chunlong, Balannik, Victoria, Pinto, Lawrence H., Lamb, Robert A., DeGrado, William F.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2011
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3116712/
https://ncbi.nlm.nih.gov/pubmed/21691418
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml100297w
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