Functional studies and modeling of pore-lining residue mutants of the influenza A virus M2 ion channel()

The A/M2 protein of influenza A virus forms a tetrameric proton selective pH-gated ion channel. The H(37)xxxW(41) motif located in the channel pore is responsible for its gating and proton selectivity. Channel activation most likely involves protonation of the H37 residues, while the conductive stat...

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Bibliographic Details
Published in:Biochemistry
Main Authors: Balannik, Victoria, Carnevale, Vincenzo, Fiorin, Giacomo, Levine, Benjamin G., Lamb, Robert A., Klein, Michael L., DeGrado, William F., Pinto, Lawrence H.
Format: Artigo
Language:Inglês
Published: 2010
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4924815/
https://ncbi.nlm.nih.gov/pubmed/20028125
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi901799k
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