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Functional studies and modeling of pore-lining residue mutants of the influenza A virus M2 ion channel()

The A/M2 protein of influenza A virus forms a tetrameric proton selective pH-gated ion channel. The H(37)xxxW(41) motif located in the channel pore is responsible for its gating and proton selectivity. Channel activation most likely involves protonation of the H37 residues, while the conductive stat...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Biochemistry
Prif Awduron: Balannik, Victoria, Carnevale, Vincenzo, Fiorin, Giacomo, Levine, Benjamin G., Lamb, Robert A., Klein, Michael L., DeGrado, William F., Pinto, Lawrence H.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2010
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4924815/
https://ncbi.nlm.nih.gov/pubmed/20028125
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi901799k
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