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BCG vaccine mediated reduction in the MHC-II expression of macrophages and dendritic cells is reversed by activation of Toll-like receptors 7 and 9

Tuberculosis is a major cause of death in mankind and BCG vaccine protects against childhood but not adult tuberculosis. BCG avoids lysosomal fusion in macrophages decreasing peptides required for activating CD4 T cells and Th1 immunity while suppressing the expression of MHC-II by antigen presentin...

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Bibliografiske detaljer
Main Authors: Bakhru, Pearl, Sirisaengtaksin, Natalie, Soudani, Emily, Mukherjee, Seema, Khan, Arshad, Jagannath, Chinnaswamy
Format: Artigo
Sprog:Inglês
Udgivet: 2013
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4096037/
https://ncbi.nlm.nih.gov/pubmed/24384074
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cellimm.2013.11.007
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