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Constant pH Molecular Dynamics in Explicit Solvent with Enveloping Distribution Sampling and Hamiltonian Exchange

[Image: see text] We present a new computational approach for constant pH simulations in explicit solvent based on the combination of the enveloping distribution sampling (EDS) and Hamiltonian replica exchange (HREX) methods. Unlike constant pH methods based on variable and continuous charge models,...

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Библиографические подробности
Главные авторы: Lee, Juyong, Miller, Benjamin T., Damjanović, Ana, Brooks, Bernard R.
Формат: Artigo
Язык:Inglês
Опубликовано: American Chemical Society 2014
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4095908/
https://ncbi.nlm.nih.gov/pubmed/25061443
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ct500175m
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