Nicastrin and Notch4 drive endocrine therapy resistance and epithelial to mesenchymal transition in MCF7 breast cancer cells

INTRODUCTION: Resistance to anti-estrogen therapies is a major cause of disease relapse and mortality in estrogen receptor alpha (ERα)-positive breast cancers. Tamoxifen or estrogen withdrawal increases the dependence of breast cancer cells on Notch signalling. Here, we investigated the contribution...

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Autores principales: Lombardo, Ylenia, Faronato, Monica, Filipovic, Aleksandra, Vircillo, Valentina, Magnani, Luca, Coombes, R Charles
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2014
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4095694/
https://ncbi.nlm.nih.gov/pubmed/24919951
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/bcr3675
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