Polygenic Scores Predict Alcohol Problems in an Independent Sample and Show Moderation by the Environment

Alcohol problems represent a classic example of a complex behavioral outcome that is likely influenced by many genes of small effect. A polygenic approach, which examines aggregate measured genetic effects, can have predictive power in cases where individual genes or genetic variants do not. In the...

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Detalhes bibliográficos
Main Authors: Salvatore, Jessica E., Aliev, Fazil, Edwards, Alexis C., Evans, David M., Macleod, John, Hickman, Matthew, Lewis, Glyn, Kendler, Kenneth S., Loukola, Anu, Korhonen, Tellervo, Latvala, Antti, Rose, Richard J., Kaprio, Jaakko, Dick, Danielle M.
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4094936/
https://ncbi.nlm.nih.gov/pubmed/24727307
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/genes5020330
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