Polygenic Risk Score Prediction of Alcohol Dependence Symptoms Across Population-Based and Clinically Ascertained Samples

BACKGROUND: Despite consistent evidence of the heritability of alcohol use disorders (AUDs), few specific genes with an etiological role have been identified. It is likely that AUDs are highly polygenic; however, the etiological pathways and genetic variants involved may differ between populations....

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Vydáno v:Alcohol Clin Exp Res
Hlavní autoři: Savage, Jeanne E., Salvatore, Jessica E., Aliev, Fazil, Edwards, Alexis C., Hickman, Matthew, Kendler, Kenneth S., Macleod, John, Latvala, Antti, Loukola, Anu, Kaprio, Jaakko, Rose, Richard J., Chan, Grace, Hesselbrock, Victor, Webb, Bradley T., Adkins, Amy, Bigdeli, Tim B., Riley, Brien P., Dick, Danielle M.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2018
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5832589/
https://ncbi.nlm.nih.gov/pubmed/29405378
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acer.13589
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