Focal Radiation Therapy Combined with 4-1BB Activation and CTLA-4 Blockade Yields Long-Term Survival and a Protective Antigen-Specific Memory Response in a Murine Glioma Model

BACKGROUND: Glioblastoma (GBM) is the most common malignant brain tumor in adults and is associated with a poor prognosis. Cytotoxic T lymphocyte antigen -4 (CTLA-4) blocking antibodies have demonstrated an ability to generate robust antitumor immune responses against a variety of solid tumors. 4-1B...

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Main Authors: Belcaid, Zineb, Phallen, Jillian A., Zeng, Jing, See, Alfred P., Mathios, Dimitrios, Gottschalk, Chelsea, Nicholas, Sarah, Kellett, Meghan, Ruzevick, Jacob, Jackson, Christopher, Albesiano, Emilia, Durham, Nicholas M., Ye, Xiaobu, Tran, Phuoc T., Tyler, Betty, Wong, John W., Brem, Henry, Pardoll, Drew M., Drake, Charles G., Lim, Michael
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2014
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4094423/
https://ncbi.nlm.nih.gov/pubmed/25013914
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0101764
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