Novel Hybrids of Natural Oridonin-Bearing Nitrogen Mustards as Potential Anticancer Drug Candidates

[Image: see text] A series of novel hybrids from natural product oridonin and nitrogen mustards were designed and synthesized to obtain more efficacious and less toxic antitumor agents. The antiproliferative evaluation showed that most conjugates were more potent than their parent compounds oridonin...

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Hlavní autoři: Xu, Shengtao, Pei, Lingling, Wang, Chengqian, Zhang, Yun-Kai, Li, Dahong, Yao, Hequan, Wu, Xiaoming, Chen, Zhe-Sheng, Sun, Yijun, Xu, Jinyi
Médium: Artigo
Jazyk:Inglês
Vydáno: American Chemical Society 2014
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4094252/
https://ncbi.nlm.nih.gov/pubmed/25050168
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml500141f
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