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Supernumerary centrosomes nucleate extra cilia and compromise primary cilium signaling

The primary cilium is a nexus of cell signaling, and ciliary dysfunction is associated with polycystic kidney disease, retinal degeneration, polydactyly, neural tube defects, and obesity (ciliopathies) [1]. Signaling molecules for cilium-associated pathways are concentrated in the cilium, and this i...

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Bibliographic Details
Main Authors: Mahjoub, Moe R., Stearns, Tim
Format: Artigo
Language:Inglês
Published: 2012
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4094149/
https://ncbi.nlm.nih.gov/pubmed/22840514
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cub.2012.06.057
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