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Supernumerary centrosomes nucleate extra cilia and compromise primary cilium signaling
The primary cilium is a nexus of cell signaling, and ciliary dysfunction is associated with polycystic kidney disease, retinal degeneration, polydactyly, neural tube defects, and obesity (ciliopathies) [1]. Signaling molecules for cilium-associated pathways are concentrated in the cilium, and this i...
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| Main Authors: | , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2012
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4094149/ https://ncbi.nlm.nih.gov/pubmed/22840514 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cub.2012.06.057 |
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