Degradation of the Deubiquitinating Enzyme USP33 Is Mediated by p97 and the Ubiquitin Ligase HERC2

Because the deubiquitinating enzyme USP33 is involved in several important cellular processes (β-adrenergic receptor recycling, centrosome amplification, RalB signaling, and cancer cell migration), its levels must be carefully regulated. Using quantitative mass spectrometry, we found that the intrac...

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Autores principales: Chan, Nickie C., den Besten, Willem, Sweredoski, Michael J., Hess, Sonja, Deshaies, Raymond J., Chan, David C.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2014
Materias:
Protein Synthesis and Degradation
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4094088/
https://ncbi.nlm.nih.gov/pubmed/24855649
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.569392
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