Phosphorylation of Cyclin-dependent Kinase 5 (Cdk5) at Tyr-15 Is Inhibited by Cdk5 Activators and Does Not Contribute to the Activation of Cdk5

Cdk5 is a member of the cyclin-dependent kinase (Cdk) family. In contrast to other Cdks that promote cell proliferation, Cdk5 plays a role in regulating various neuronal functions, including neuronal migration, synaptic activity, and neuron death. Cdks responsible for cell proliferation need phospho...

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Autors principals: Kobayashi, Hiroyuki, Saito, Taro, Sato, Ko, Furusawa, Kotaro, Hosokawa, Tomohisa, Tsutsumi, Koji, Asada, Akiko, Kamada, Shinji, Ohshima, Toshio, Hisanaga, Shin-ichi
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2014
Matèries:
Signal Transduction
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4094073/
https://ncbi.nlm.nih.gov/pubmed/24872417
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.501148
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