Multimerization of Glycosylphosphatidylinositol-anchored High Density Lipoprotein-binding Protein 1 (GPIHBP1) and Familial Chylomicronemia from a Serine-to-Cysteine Substitution in GPIHBP1 Ly6 Domain

GPIHBP1, a glycosylphosphatidylinositol-anchored glycoprotein of microvascular endothelial cells, binds lipoprotein lipase (LPL) within the interstitial spaces and transports it across endothelial cells to the capillary lumen. The ability of GPIHBP1 to bind LPL depends on the Ly6 domain, a three-fin...

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Main Authors: Plengpanich, Wanee, Young, Stephen G., Khovidhunkit, Weerapan, Bensadoun, André, Karnman, Hirankorn, Ploug, Michael, Gårdsvoll, Henrik, Leung, Calvin S., Adeyo, Oludotun, Larsson, Mikael, Muanpetch, Suwanna, Charoen, Supannika, Fong, Loren G., Niramitmahapanya, Sathit, Beigneux, Anne P.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2014
Assuntos:
Molecular Bases of Disease
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4094059/
https://ncbi.nlm.nih.gov/pubmed/24847059
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.558528
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