The Mitochondrial Protein NLRX1 Controls the Balance between Extrinsic and Intrinsic Apoptosis

NLRX1 is a mitochondrial Nod-like receptor (NLR) protein whose function remains enigmatic. Here, we observed that NLRX1 expression was glucose-regulated and blunted by SV40 transformation. In transformed but not primary murine embryonic fibroblasts, NLRX1 expression mediated resistance to an extrins...

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Autores principales: Soares, Fraser, Tattoli, Ivan, Rahman, Muhammed A., Robertson, Susan J., Belcheva, Antoaneta, Liu, Daniel, Streutker, Catherine, Winer, Shawn, Winer, Daniel A., Martin, Alberto, Philpott, Dana J., Arnoult, Damien, Girardin, Stephen E.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2014
Materias:
Immunology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4094044/
https://ncbi.nlm.nih.gov/pubmed/24867956
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.550111
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