Population pharmacokinetics and Bayesian estimation of tacrolimus exposure in paediatric liver transplant recipients

AIMS: The objectives of this study were to develop a population pharmacokinetic (PopPK) model for tacrolimus in paediatric liver transplant patients and determine optimal sampling strategies to estimate tacrolimus exposure accurately. METHODS: Twelve hour intensive pharmacokinetic profiles from 30 p...

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Bibliographische Detailangaben
Hauptverfasser: Kassir, Nastya, Labbé, Line, Delaloye, Jean-Romain, Mouksassi, Mohamad-Samer, Lapeyraque, Anne-Laure, Alvarez, Fernando, Lallier, Michel, Beaunoyer, Mona, Théorêt, Yves, Litalien, Catherine
Format: Artigo
Sprache:Inglês
Veröffentlicht: Blackwell Science Inc 2014
Schlagworte:
Paediatric Clinical Pharmacology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4093930/
https://ncbi.nlm.nih.gov/pubmed/24977292
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.12276
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