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Tacrolimus dose requirements in paediatric renal allograft recipients are characterized by a biphasic course determined by age and bone maturation

AIMS: Despite longstanding recognition of significant age‐dependent differences in drug disposition during childhood, the exact course and the underlying mechanisms are not known. Our aim was to determine the course and determinants of individual relative dose requirements, during long‐term follow‐u...

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Veröffentlicht in:Br J Clin Pharmacol
Hauptverfasser: Knops, Noël, Herman, Jean, van Dyck, Maria, Ramazani, Yasaman, Debbaut, Edward, van Damme‐Lombaerts, Rita, Levtchenko, Elena, van den Heuvel, Lambertus P., Fieuws, Steffen, Kuypers, Dirk
Format: Artigo
Sprache:Inglês
Veröffentlicht: John Wiley and Sons Inc. 2016
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5346878/
https://ncbi.nlm.nih.gov/pubmed/27966227
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.13174
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