Determinants for Membrane Association of the Hepatitis C Virus NS2 Protease Domain

Hepatitis C virus (HCV) nonstructural protein 2 (NS2) is required for HCV polyprotein processing and particle assembly. It comprises an N-terminal membrane domain and a C-terminal, cytosolically oriented protease domain. Here, we demonstrate that the NS2 protease domain itself associates with cellul...

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Autors principals: Lange, Christian M., Bellecave, Pantxika, Dao Thi, Viet Loan, Tran, Huong T. L., Penin, François, Moradpour, Darius, Gouttenoire, Jérôme
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2014
Matèries:
Genome Replication and Regulation of Viral Gene Expression
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4093864/
https://ncbi.nlm.nih.gov/pubmed/24648458
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00224-14
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