An Epistatic Relationship between the Viral Protein Kinase UL97 and the UL133-UL138 Latency Locus during the Human Cytomegalovirus Lytic Cycle

We report that UL133-UL138 (UL133/8), a transcriptional unit within the ULb′ region (ULb′) of the human cytomegalovirus (HCMV) genome, and UL97, a viral protein kinase encoded by HCMV, play epistatic roles in facilitating progression of the viral lytic cycle. In studies with HCMV strain TB40/E, phar...

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Detalhes bibliográficos
Main Authors: Li, Gang, Rak, Michael, Nguyen, Christopher C., Umashankar, Mahadevaiah, Goodrum, Felicia D., Kamil, Jeremy P.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2014
Assuntos:
Genome Replication and Regulation of Viral Gene Expression
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4093856/
https://ncbi.nlm.nih.gov/pubmed/24623439
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00447-14
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