Complex Expression of the UL136 Gene of Human Cytomegalovirus Results in Multiple Protein Isoforms with Unique Roles in Replication

Human cytomegalovirus (HCMV) is a complex DNA virus with a 230-kb genome encoding 170 and up to 750 proteins. The upper limit of this coding capacity suggests the evolution of complex mechanisms to substantially increase the coding potential from the 230-kb genome. Our work examines the complexity o...

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Bibliographic Details
Published in:J Virol
Main Authors: Caviness, Katie, Cicchini, Louis, Rak, Michael, Umashankar, Mahadevaiah, Goodrum, Felicia
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2014
Subjects:
Genome Replication and Regulation of Viral Gene Expression
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4249117/
https://ncbi.nlm.nih.gov/pubmed/25297993
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02711-14
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