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Reduction of insulin gene transcription in HIT-T15 beta cells chronically exposed to a supraphysiologic glucose concentration is associated with loss of STF-1 transcription factor expression.

Chronic exposure of HIT-T15 beta cells to elevated glucose concentrations leads to decreased insulin gene transcription. The reduction in expression is accompanied by diminished binding of a glucose-sensitive transcription factor (termed GSTF) that interacts with two (A+T)-rich elements within the 5...

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Bibliographische Detailangaben
Hauptverfasser: Olson, L K, Sharma, A, Peshavaria, M, Wright, C V, Towle, H C, Rodertson, R P, Stein, R
Format: Artigo
Sprache:Inglês
Veröffentlicht: 1995
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC40937/
https://ncbi.nlm.nih.gov/pubmed/7568086
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