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Inhibition of Human Dyskerin as a New Approach to Target Ribosome Biogenesis
The product of the DKC1 gene, dyskerin, is required for both ribosome biogenesis and telomerase complex stabilization. Targeting these cellular processes has been explored for the development of drugs to selectively or preferentially kill cancer cells. Presently, intense research is conducted involv...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Public Library of Science
2014
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4092089/ https://ncbi.nlm.nih.gov/pubmed/25010840 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0101971 |
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