Mechanism of IRSp53 inhibition and combinatorial activation by Cdc42 and downstream effectors

The Rho family GTPase effector IRSp53 has essential roles in filopodia formation and neuronal development, but its regulatory mechanism is poorly understood. IRSp53 contains a membrane-binding BAR domain followed by an unconventional CRIB motif that overlaps with a proline-rich region (CRIB–PR) and...

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Main Authors: Kast, David J, Yang, Changsong, Disanza, Andrea, Boczkowska, Malgorzata, Madasu, Yadaiah, Scita, Giorgio, Svitkina, Tatyana, Dominguez, Roberto
Formato: Artigo
Idioma:Inglês
Publicado: 2014
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4091835/
https://ncbi.nlm.nih.gov/pubmed/24584464
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.2781
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