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Immunogenic and tolerogenic effects of the chimeric IL-2-diphtheria toxin cytocidal agent Ontak(®) on CD25(+) cells
Ontak(®), a conjugate between IL-2 and a diphtheria toxin fragment, was recently investigated in cancer clinical trials aiming to kill CD25(+) regulatory T cells (T(regs)). We found that the activity of Ontak(®) was more complex on T(regs) and conventional T cells (T(convs)) than anticipated, includ...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Landes Bioscience
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4091105/ https://ncbi.nlm.nih.gov/pubmed/25050193 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/onci.28223 |
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