Defective Neutrophil Recruitment in Leukocyte Adhesion Deficiency Type I Disease Causes Local IL-17-driven Inflammatory Bone Loss

Leukocyte adhesion deficiency Type I (LAD-I), a disease syndrome associated with frequent microbial infections, is caused by mutations on the CD18 subunit of β(2) integrins. LAD-I is invariably associated with severe periodontal bone loss, historically attributed to lack of neutrophil surveillance o...

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Main Authors: Moutsopoulos, Niki, Konkel, Joanne, Sarmadi, Mojgan, Eskan, Mehmet A., Wild, Teresa, Dutzan, Nicolas, Abusleme, Loreto, Zenobia, Camille, Hosur, Kavita B., Abe, Toshiharu, Uzel, Gulbu, Chen, WanJun, Chavakis, Triantafyllos, Holland, Steven M., Hajishengallis, George
Format: Artigo
Language:Inglês
Published: 2014
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4090608/
https://ncbi.nlm.nih.gov/pubmed/24670684
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.3007696
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