Interleukin-12 and Interleukin-23 Blockade in Leukocyte Adhesion Deficiency Type 1

A patient with leukocyte adhesion deficiency type 1 (LAD1) had severe periodontitis and an intractable, deep, nonhealing sacral wound. We had previously found a dominant interleukin-23–interleukin-17 signature at inflamed sites in humans with LAD1 and in mouse models of the disorder. Blockade of thi...

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Detalhes bibliográficos
Publicado no:N Engl J Med
Main Authors: Moutsopoulos, Niki M., Zerbe, Christa S., Wild, Teresa, Dutzan, Nicolas, Brenchley, Laurie, DiPasquale, Giovanni, Uzel, Gulbu, Axelrod, Karen C., Lisco, Andrea, Notarangelo, Lucia D., Hajishengallis, George, Notarangelo, Luigi D., Holland, Steven M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5494261/
https://ncbi.nlm.nih.gov/pubmed/28328326
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1056/NEJMoa1612197
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