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SUMO1 modification stabilizes CDK6 protein and drives the cell cycle and glioblastoma progression
Ubiquitination governs oscillation of cyclin-dependent kinase (CDK) activity through a periodic degradation of cyclins for orderly cell cycle progression; however, the mechanism that maintains the constant CDK protein levels throughout the cell cycle remains unclear. Here we show that CDK6 is modifi...
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| Autores principales: | , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2014
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4090607/ https://ncbi.nlm.nih.gov/pubmed/24953629 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms5234 |
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