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SUMO1 modification stabilizes CDK6 protein and drives the cell cycle and glioblastoma progression

Ubiquitination governs oscillation of cyclin-dependent kinase (CDK) activity through a periodic degradation of cyclins for orderly cell cycle progression; however, the mechanism that maintains the constant CDK protein levels throughout the cell cycle remains unclear. Here we show that CDK6 is modifi...

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Detalhes bibliográficos
Main Authors: Bellail, Anita C., Olson, Jeffrey J., Hao, Chunhai
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4090607/
https://ncbi.nlm.nih.gov/pubmed/24953629
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms5234
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