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A role for the NLRP3 inflammasome in metabolic diseases and did Warburg miss inflammation?
The inflammasome is a protein complex that is comprised of an intracellular sensor that is typically an NLR protein, the pro-protein, procaspase-1 and adaptor molecule ASC. Inflammasome activation leads to caspase-1 maturation and the processing of its substrate, IL-1β and IL-18. Although initially...
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| Main Authors: | , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2012
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4090390/ https://ncbi.nlm.nih.gov/pubmed/22430788 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.2228 |
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