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A role for the NLRP3 inflammasome in metabolic diseases and did Warburg miss inflammation?

The inflammasome is a protein complex that is comprised of an intracellular sensor that is typically an NLR protein, the pro-protein, procaspase-1 and adaptor molecule ASC. Inflammasome activation leads to caspase-1 maturation and the processing of its substrate, IL-1β and IL-18. Although initially...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Wen, Haitao, Ting, Jenny P-Y., O’Neill, Luke A.J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2012
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4090390/
https://ncbi.nlm.nih.gov/pubmed/22430788
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.2228
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