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The Inflammasome NLRs in Immunity, Inflammation, and Associated Diseases
Inflammasome activation leads to caspase-1 activation, which causes the maturation cleavage of pro-IL-1β and pro-IL-18. A subgroup of the NLR (nucleotide-binding domain, leucine-rich repeat containing) proteins are key mediators of the inflammasome. Studies of gene-deficient mice and cells have impl...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4067317/ https://ncbi.nlm.nih.gov/pubmed/21219188 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1146/annurev-immunol-031210-101405 |
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