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Variola Type IB DNA Topoisomerase: DNA Binding and Supercoil Unwinding Using Engineered DNA Minicircles

[Image: see text] Type IB topoisomerases unwind positive and negative DNA supercoils and play a key role in removing supercoils that would otherwise accumulate at replication and transcription forks. An interesting question is whether topoisomerase activity is regulated by the topological state of t...

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Autores principales: Anderson, Breeana G., Stivers, James T.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Chemical Society 2014
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4089885/
https://ncbi.nlm.nih.gov/pubmed/24945825
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi500571q
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