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Fibrinogen Hershey IV: A Novel Dysfibrinogen with a γ V411I Mutation in the Integrin αIIbβ3 Binding Site
The carboxyl terminal segment of the fibrinogen γ chain from γ 408–411 plays a crucial role in platelet aggregation via interactions with the platelet receptor αIIbβ3. We describe here the first naturally-occurring fibrinogen point mutation affecting this region and demonstrate its effects on platel...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4089099/ https://ncbi.nlm.nih.gov/pubmed/18521501 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1160/TH07-06-0427 |
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