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Autophagic-lysosomal dysregulation downstream of cathepsin B inactivation in human skin fibroblasts exposed to UVA
Recently, using 2D-DIGE proteomics we have identified cathepsin B as a novel target of UVA in human Hs27 skin fibroblasts. In response to chronic exposure to noncytotoxic doses of UVA (9.9 J/cm(2), twice a week, 3 weeks), photooxidative impairment of cathepsin B enzymatic activity occurred with accu...
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| Autores principales: | , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2011
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4089038/ https://ncbi.nlm.nih.gov/pubmed/21773629 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c1pp05131h |
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