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Increasing the affinity of selective bZIP-binding peptides through surface residue redesign

The coiled-coil dimer is a prevalent protein interaction motif that is important for many cellular processes. The basic leucine-zipper (bZIP) transcription factors are one family of proteins for which coiled-coil mediated dimerization is essential for function, and misregulation of bZIPs can lead to...

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Библиографические подробности
Главные авторы: Kaplan, Jenifer B, Reinke, Aaron W, Keating, Amy E
Формат: Artigo
Язык:Inglês
Опубликовано: Blackwell Publishing Ltd 2014
Предметы:
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4088978/
https://ncbi.nlm.nih.gov/pubmed/24729132
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.2477
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