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Dynamic Equilibrium of B7-1 Dimers and Monomers Differentially Affects Immunological Synapse Formation and T Cell Activation in Response to TCR/CD28 Stimulation
Under steady-state conditions, B7-1 is present as a mixed population of noncovalent dimers and monomers on the cell surface. In this study, we examined the physiological significance of this unique dimer–monomer equilibrium state of B7-1. We demonstrate that altering B7-1 to create a uniformly coval...
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| Autori principali: | , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2010
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4088257/ https://ncbi.nlm.nih.gov/pubmed/20065109 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.0902869 |
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